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KMID : 0939920030350010016
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대한암학회지
2003 Volume.35 No. 1 p.16 ~ p.24
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Immunohistochemical Evaluation of E-cadherin/catenin (α-, β-, γ-catenin and p120CTN) Complex Expression in Early Gastric Cancer
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Jo Tae-Yong
Jeon Tae-Yong
Chae Kyu-Hwang
Kim Dong-Heon
Park Do-Youn
Suh Kang-Seuk
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Abstract
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Purpose: The significance of abnormal E-cadherin/catenin complex expression and the correlation of each of its components in cancer remain unclear. This study aimed to characterize the clinical significance of the abnormal membrane
expression of
the E-cadherin/catenin complex and the localization patterns of the β-catenin and p120CTN in early gastric cancer.
Materials and Methods: Immunohistochemical staining for E-cadherin, α-, β- and γ-catenin and p120CTN were performed on 47 early gastric cancer specimens. The patterns of membrange expression of the E-cadherin/catenin complex,
and
the localization patterns of the β-catenin and p120CTN, were semi quantitatively graded as loss, reduced, preserved or negative and positive.
Results: An abnormal immunoreactivity of at least one of E-cadherin/catenin complex proteins was noted in 46 (97.8%) of the 47 early gastric cancer cases. There were no significant correlations of the membrane E-cadherin/catenin expression
with,
either, sex, age, location, size, macroscopic type, depth of invasion or lymphovascular invasion. Abnormal expressions of membrane E-cadherin, β-catenin and γ-catenin were more frequent in the diffuse-type than in the intestinal type. No linear
correlation was shown for the β-catenin between the membrane and cytoplasmic expressions. Nuclear staining of the β-catenin was observed in 5 (10.6%) cases, but nuclear staining of the p120CTN, a promotor of Kaiso transcriptional
factor,
was not seen.
Conclusion: These results suggest that alterations of the E-cadherin/catenin complex may be involved in the early stages of gastric cancer. Although β-catenin functions as a transcriptional factor, the inactivation of membrane E-cadherin
does
not appear to result in significant increases in the level of cytoplasmic β-catenin. Kaiso transcriptional factor may not be involved in the early carcinogenesis of gastric cancer.
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KEYWORD
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Stomach neoplasm, Cell adhesion, Cadherin, Catenin
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